Vitamin D Supplementation Associated with Improved LDL Cholesterol Among Postmenopausal Women

Postmenopausal women who gain elevated serum 25-hydroxyvitamin D3 
through supplementation see reductions in LDL cholesterol, according 
to a study in Menopause.

Researchers measured lipids among some 600 Women’s Health Initiative 
participants who’d been randomized to receive either daily vitamin D 
(400 IU) plus calcium (1000 mg), or placebo. At 2 years, the mean 
serum vitamin D level was significantly higher in the supplement 
versus placebo group (24.3 vs. 18.2 ng/mL). Further, supplement 
recipients had a 4.5-mg/dL decrease in LDL cholesterol relative to 
placebo recipients — an effect mediated by serum vitamin D levels.

The researchers conclude: “Although further studies are needed to 
determine whether these findings translate into clinically meaningful 
results, this should be viewed as a reminder that women at higher risk 
for 25OHD3 deficiency should consider supplementation” with calcium 
and vitamin D.


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