Combining antidepressants especially SSRI’s (Lexapro, Zoloft, etc.) and nonsteroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen, Naprosen might increase the risk for strokes from bleeding in the brain, in patients according to a study published in the BMJ.

Building on the established knowledge that NSAIDs and antidepressants independently increase the risk for abnormal bleeding, researchers examined data on hospital admissions and prescriptions from more than 4 million Korean patients who were prescribed antidepressants for the first time between 2010 and 2013.

Individuals who took both antidepressants and NSAIDs at the same time were at a heightened risk for experiencing bleeding in the brain within 30 days of beginning the drugs, compared with those who used antidepressants alone.