Oophorectomy Reduces Cancer Risk, Mortality in Women with BRCA Mutations

Women with BRCA1 or 2 mutations who undergo oophorectomy have 
dramatically reduced risks for all-cause mortality and for cancers of 
the ovaries, fallopian tubes, or peritoneum, according to a Journal of 
Clinical Oncology study.

Researchers followed some 5800 women with a mutation in either gene 
for an average of 5.6 years. Relative to those with intact ovaries, 
those who self-reported having undergone either bilateral oophorectomy 
or salpingo-oophorectomy had an adjusted hazard ratio for ovarian, 
fallopian tube, or peritoneal cancer of 0.20. Their hazard ratio for 
all-cause mortality was 0.23.

Journal of Clinical Oncology

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