Women with BRCA1 or 2 mutations who undergo oophorectomy have
dramatically reduced risks for all-cause mortality and for cancers of
the ovaries, fallopian tubes, or peritoneum, according to a Journal of
Clinical Oncology study.
Researchers followed some 5800 women with a mutation in either gene
for an average of 5.6 years. Relative to those with intact ovaries,
those who self-reported having undergone either bilateral oophorectomy
or salpingo-oophorectomy had an adjusted hazard ratio for ovarian,
fallopian tube, or peritoneal cancer of 0.20. Their hazard ratio for
all-cause mortality was 0.23.
Journal of Clinical Oncology